In the most prominent Renaissance or early modern work on melancholy, The Anatomy of Melancholy, published in 1621, the Oxford scholar Robert Burton (1577–1640) suggested that insufficient exercise, idleness, isolation, fear, shame, hatred, envy, anger, the love of gambling and excessive pleasure, pride, self-obsession, over-work, too much studying, frights, infatuations, rejections, imprisonment and poverty could all lead to mental illness. According to Burton, the cure for melancholy was to address these aspects of the patient’s life. Moderate exercise of the body and mind, outdoor recreation, music and laughter, friendly company and the alleviation of poverty were all capable of reviving ailing spirits and restoring sanit