This is an edition and translation of a traditional healer's notebook from Crete. It belongs to the genre of iatrosophia: practical manuals of collected healing wisdom with admixtures of agricultural and household lore and elements of religious, astrological and magical beliefs. At its core lies material from earlier classical and Byzantine medical traditions. This is the first iatrosophion to be translated into English; introductory essays and notes to the translation provide context and the information necessary for appreciating the text and the abundant materia medica of the notebook is treated in a substantial appendix.