Are our brains hardwired to be left-wing or right-wing? How did mental health become a hot political issue? What advice can brain scientists give politicians to help get their message across? This week David interviews Professor Barbara Sahakian – the renowned neuropsychologist who has worked with the U.K. government on questions of mental health and well-being – to discover the lessons of new scientific research for our politics. The team then discuss the Labour and Conservative manifestos and the inner tensions they reveal within the parties, and what their pledges really mean in an age of coalitions and compromise. And, in the week when Hilary Clinton declared her presidential candidacy, we debate the time spans of political campaigns in the UK and the U.S., and the different ways the two countries do politics.