Podcast: Discovery

In recent decades, we have taken huge steps forward in treating formerly fatal viruses - with pharmacological breakthroughs revolutionising treatment for conditions such as HIV, hepatitis and herpes. Raymond Schinazi has played a big role in that revolution.Ray was born in Egypt, where his mother’s brush with a potentially deadly illness during his childhood inspired a fascination with medicine. His childhood was scattered; after his family were forced to leave their homeland and travelled to Italy as refugees, Ray ended up on a scholarship to a British boarding school - and subsequently went on to study and flourish in the world of chemistry and biology.Today, Ray is the director of the Laboratory of Biochemical Pharmacology at Emory University in Atlanta, where he also set up the renowned Center for AIDS Research. His work in the early days of HIV studies led to drugs that many with the virus still take today; while his contribution to developing a cure for Hepatitis C has saved millions of lives around the world.Speaking to Jim al-Khalili, Ray reflects on his route to success and explains why he is confident that more big breakthroughs are on the horizon.

From anorexia nervosa to binge-eating, eating disorders are potentially fatal conditions that are traditionally very difficult to diagnose and treat - not least because those affected often don’t recognise that there’s anything wrong. But also because of the diverse factors that can influence and encourage them.Janet Treasure is a Professor of Psychiatry at King’s College, London - where she's focused on understanding the drivers behind these disorders, to help develop more effective treatments. Her study of twins in the 1980s offered one of the earliest arguments of a genetic link to anorexia, rather than the purely psychological motivations accepted at the time; while her most recent work explores holistic ways to better treat these conditions.Speaking to Jim Al-Khalili, Janet explains the work that's revealed anorexia's roots in both body and mind - as well as how attitudes towards eating disorders are slowly changing.

Marfan syndrome is a genetic disorder that makes renders the body’s connective tissues incredibly fragile; this can weaken the heart, leading to potentially fatal aneurysms. What’s more, anyone with the condition has a 50/50 chance of passing it on to their children.Dr Anne Child is a clinical geneticist who’s dedicated her professional life to finding answers and solutions for people affected by Marfan’s.Born in Canada, she met her British future-husband while working in Montreal in a case she describes as "love at first sight" - and in the 1970s she relocated her life to the UK.There, an encounter with a Marfan patient she was unable to help set Anne on a career path for life. She subsequently established the team that discovered the gene responsible for Marfan's, and founded the Marfan Trust to drive further research. Since then, life expectancy for those with the condition has jumped from 32 years old, to over 70.Speaking to Professor Jim Al-Khalili, Anne shares how she and her team achieved this remarkable turnaround.

Many of us have heard of seismology, the study of earthquakes; but what about asteroseismology, focusing on vibrations in stars?Conny Aerts is a Professor of Astrophysics at the University of Leuven in Belgium - and a champion of this information-rich field of celestial research. Her work has broken new ground in helping to improve our understanding of stars and their structures.It hasn’t been an easy path: Conny describes herself as always being “something of an outlier” and she had to fight to follow her dream of working in astronomy.
But that determination has paid off - today, Conny is involved in numerous interstellar studies collecting data from thousands of stars, and taking asteroseismology to a whole new level.In an epsiode recorded at the 2024 Cheltenham Science Festival, Professor Jim Al-Khalili talks to the pioneering Belgian astrophysicist about her lifelong passion for stars, supporting the next generation of scientists, and her determination to tread her own path.

When does a crowd of people become unsafe? How well will the football team Aston Villa do next season? When is it cost-effective to replace a kitchen? The answers may seem arbitrary but, to Nira Chamberlain, they lie in mathematics. You can use maths to model virtually anything.

A top secret little-known mission that changed the outcome of World War II. Not Alan Turing's Enigma code-breaking mission but a daring foray, conducted behind enemy lines on the shores of Normandy. Harrison Lewis and wetland scientist Christian Dunn re-enact one of the most remarkable feats of the Second World War and discover the intricate details of the daring but forgotten science that underpinned D-Day.

Take a trip around the supermarket and you'll see shelves of products claiming to be 'high in protein'. Scroll through your social media and you'll find beautiful, sculpted people offering recipes and ideas for packing more protein into your diet.Science presenters Dr Julia Ravey and Dr Ella Hubber have noticed this too. They wanted to unpick the protein puzzle to find out what it does in our bodies and how much we really need. Can this macronutrient really help us lose weight, get fit and be healthier?Along the way, they speak to Professor Giles Yeo from the University of Cambridge, Bridget Benelam from the British Nutrition Foundation, Paralympian hopeful Harrison Walsh, and food historian Pen Vogler.Presenters: Dr Julia Ravey and Dr Ella Hubber
Producer: Alice Lipscombe-Southwell
Editor: Martin SmithCredits: @thefitadam/@TSCPodcast/@tadhgmoody/@meg_squats/@aussiefitness

What is the universe made of? Where does space dust come from? And how exactly might one go about putting on a one-man-show about Sir Isaac Newton?These are all questions that Mike Edmunds, Emeritus Professor of Astrophysics at Cardiff University and President of the Royal Astronomical Society (RAS), has tackled during his distinguished career. And although physics is his first love, Mike is fascinated by an array of scientific disciplines - with achievements ranging from interpreting the spread of chemical elements in the Universe, to decoding the world’s oldest-known astronomical artefact.Recording in front of an audience at the RAS in London, Professor Jim Al-Khalili talks to Mike about his life, work and inspirations. And who knows, Sir Isaac might even make an appearance…

With 86 billion nerve cells joined together in a network of 100 trillion connections, the human brain is the most complex system in the known universe.Dr Hannah Critchlow is an internationally acclaimed neuroscientist who has spent her career demystifying and explaining the brain to audiences around the world. Through her writing, broadcasting and lectures to audiences – whether in schools, festivals or online – she has become one of the public faces of neuroscience.She tells Prof Jim Al-Khalili that her desire to understand the brain began when she spent a year after school as a nursing assistant in a psychiatric hospital. The experience of working with young patients - many the same age as her - made her ask what it is within each individual brain which determines people’s very different life trajectories.In her books she explores the idea that much of our character and behaviour is hard-wired into us before we are even born. And most recently she has considered collective intelligence, asking how we can bring all our individual brains together and harness their power in one ‘super brain’.And we get to hear Jim’s own mind at work as Hannah attaches electrodes to his head and turns his brain waves into sound.

The reputation of the nuclear industry has had highs and lows during the career of Dr Fiona Rayment, the President of the Nuclear Institute. But nowadays the role of nuclear science and engineering has become more widely accepted in the quest for carbon net zero.Growing up in Hamilton, Scotland during a time of energy insecurity, Fiona was determined to understand more about why her school lacked the energy to heat up all of the classrooms or why there were power cuts causing her to have to do her homework by candlelight - and in nuclear she knew there was a possible solution.But it’s not just in clean energy that Fiona has spent her career, she’s also been involved in investigating how nuclear science can be used in treating cancer and space travel, as well as promoting gender diversity in the nuclear industry.Speaking to Professor Jim Al-Khalili, Fiona discusses how she’s always tried to keep close to the science during her career in order to keep her ‘spark’!

Dr Sheila Willis is a forensic scientist who was Director General of Forensic Science Ireland for many years.She has spent her life using science to help solve cases, working on crime scenes and then analysing material in the lab, and presenting scientific evidence in court.It’s a complicated business. Forensic science relies on powerful technology, such as DNA analysis, but it cannot be that alone - it’s also about human judgement, logical reasoning and asking the right questions.It is these fundamentals of forensic science that Sheila has fought for through her long career and what she fears may be becoming lost from the field now.We find out what happens when the two very different worlds of science and the law clash in the courtroom. How to walk the line of presenting scientific evidence where there is pressure to be definitive where often science cannot be - and what this part of the job has in common with food packaging.And what makes a good forensic scientist?We’ll turn the studio at London’s Broadcasting House into a live crime scene to see if host Professor Jim Al-Khalili would be any good as a forensic investigator…

Professor Charles Godfray, Director of the the Oxford Martin School tells Jim Al-Kahlili about the intricate world of population dynamics, and how a healthy obsession with parasitic wasps might help us solve some of humanity's biggest problems, from the fight against Malaria to sustainably feeding a global community of 9 billion people.

Sir Jonathan Van-Tam, or ‘JVT’ as he's arguably better known, first came to widespread public attention in his role as Deputy Chief Medical Officer during the Covid-19 pandemic.But even before that, Jonathan had built an impressive career based on a long-held fascination with respiratory illness and infectious diseases. He’s worked across the public and private sectors, contributing significantly to improving our understanding of influenza and treatments to address such viruses.It’s hard to believe that back in his teens, JVT – the man who advised the nation on pandemic precautions and helped make the UK’s vaccine roll-out possible – nearly didn’t get the grades he needed to go to medical school. But early challenges aside, Jonathan went on to discover a love for both medical research and public speaking: making complex public health messages easier to digest – not least by using analogies relating to his beloved football.Speaking to Professor Jim Al-Khalili in the first episode of a new series of The Life Scientific, Jonathan discusses his life and career: from academic emphasis in childhood and imposter syndrome at medical school, to pandemic pressures around Covid-19 and big birthday celebrations.

Dr Chris van Tulleken wrestles with the dilemma of slaughter. Could he bring himself to dispatch an animal himself? Is he happy supporting an industry which kills animals in his name? And if not, what could he eat instead?Chris explores the rise of the alternative protein industry – plant-based meat alternatives, lab-grown meat, or most shocking of all for some, actual meat abstinence, Veganism.And it is time to revisit that initial question: what’s influencing our choices when it comes to eating chicken, what impact is that having – and are we bothered?

We're a planet addicted to chicken - and our appetites fuel a massive global industry... but is it one we should support?As Chris wrestles with how he personally feels about this weird and wonderful bird, he decides to take a look at the business as a whole: a global industry that's cited by some as a shining example of a super-efficient food production system, one that could help drive food security around the world.But others say it’s a cruel, destructive and outdated structure that makes a few people richer while exploiting others – along with animals and the environment.In Brazil, one of the world’s biggest chicken and soya producers, our reporter Leonardo Milano hears accusations of threats and pollution relating to the feed sector; while in Africa, Chris learns about poultry-farming initiatives helping to make struggling nations more food-secure.And then there are the other challenges that the industry is wrestling with: from antimicrobial resistance to the threat of another major global pandemic, potentially stemming from chicken farms…So is there a ‘big business bad guy’ to blame – or does responsibility lie closer to home, with unquestioning consumers like Chris?

Chris has learned how to make better chicken choices, and what those choices really mean.So why is he STILL eating RUBBISH?Like many of us, Chris is always trying to eat better food: healthy, high welfare, good for the environment. This kind of consumer demand is making the chicken industry better, in tiny increments. So why do so many of us give ourselves a pass when it comes to the food we KNOW we shouldn’t be eating, yet we do in absolutely vast amounts… fast food?Chicken is at the very heart of this industry. As a cheap meat that doesn’t have a strong taste, can easily take on other flavours and doesn’t have any religious restrictions, it’s the ideal takeaway ingredient; from nuggets to chow mein to tikka masala.And although we might be careful about chicken choices when buying it raw to prepare at home, somehow we don’t seem to mind turning a blind eye to the origins and nutritional content of our fast food favourites, especially if we’re hungry…Chris discovers just how bad this food can be for both us and the planet, and why we’re powerless to resist it.

For eons, salt has been crucial to human health, culture, and diet. On this episode of The Evidence, we explore the strange science of salt taste – why it can be sweet, salty, or even a flavour enhancer. We look at how salt keeps our bodies running, and what happens if we have to little of it. And while too little salt may be bad, too much is also a problem. What does the science say about how much salt is optimal, and what can we do to make sure we’re eating the right amount? Claudia Hammond is joined by a panel of salty experts who will help find the answers to these questions and more.

Do YOU know what you're eating? Are you sure?Dr Chris van Tulleken is keen to make good food choices, and buy the best chicken possible for his dinner. High welfare, tasty, and good for the environment, ideally. But it's not as easy as that. How CAN he make good food choices if he has no idea what he's buying?Chris explores what we actually know about the food we buy, and to what extent we can trust what's on a label.He also uncovers the startling truth about two very different ways that we buy chicken - lifting the lid on why sometimes, even the most moral meat shoppers turn a blind eye...

We’ve heard about the potential problems around chicken welfare. But how does that square with their impact on the environment?Dr Chris van Tulleken finds out what it takes to produce the most eco-friendly chicken meat possible. And makes a devastating discovery. Welfare concerns, and environmental credentials, often pull in OPPOSITE directions. Does he want to eat the happiest birds, or the ones kindest to the planet?Halfway through his poultry quest, Chris remains massively conflicted: he loves chicken, but some of what he’s discovered makes him question how much he eats it. Will he still be able to look at it the same way as he goes deeper down the rabbit hole? And more importantly, should he keep serving it up to the family?

We eat chicken. A LOT of it. We might love the taste, but what about how we're treating those birds?After witnessing first-hand the reality of indoor chicken farming - how most of the chicken we eat is raised - Dr Chris van Tulleken wants to know: are the birds happy enough, or is our method of rearing cheap chicken actually cruel?If so, what’s the ‘happier’ alternative – and do carnivores like Chris care enough to pay the price for that, or does a love of meat ultimately trump ethics?Chris battles with his conscience, and finds the answer hard to stomach.