Asia is the world's largest e-commerce marketplace and continues to grow rapidly. Some countries lead. Others need to catch up. An efficient e-commerce marketplace requires information and communication technology infrastructure—including internet access, speed, and affordability—along with logistics, an effective legal and institutional framework, and social acceptance and awareness. This report reviews the opportunities and challenges in developing business-to-consumer e-commerce in the region. It also examines how Fourth Industrial Revolution technologies—blockchains, the internet of things, machine learning, artificial intelligence, and 5G wireless networks, among others—will transform the industry and unlock its dynamic potential. It also offers policy recommendations to help lower barriers to e-commerce development.