The Highest House on the Mountain examines the tension between brothers, fathers and sons. When Mikey's son Patrick comes to visit with his new wife, he is quickly followed by his brother Connie, a scheming ne’er-do-well who sets out to destroy Patrick’s marriage and Mikey’s bond with his brother Sonny. The only escape from the final tragedy is to the highest house on the mountain, where those who’ve had ‘enough of bitterness’ can take refuge.