How to treat and cure Canker in the equine hoof. Canker generally originates in the frog and can be mistaken for thrush, even sheared heel in the early stages. The condition is frequently but not always accompanied by a foul odor and a texture that resembles rotten cauliflower. It mainly affects the frog but can encompass the soul as well. The combination of thorough debridement coupled with the following treatment plan should work.