This Safety Guide provides recommendations on radiation protection and radioactive waste management in the design and operation of research reactors, to meet the relevant requirements of IAEA Safety Standards Series No. SSR-3, Safety of Research Reactors. It identifies important components that should be considered at the design stage with regard to facilitating radiation protection and radioactive waste management. It also recommends good practices in implementing operational radiation protection and radioactive waste management programmes, and in their optimization. This Safety Guide is a revision of IAEA Safety Standards Series No. NS-G-4.6, which it supersedes.