Medical X-ray equipment technology has evolved exponentially in the last decades, shifting steadily from analogue to digital radiology, from single slice to multidetector-row computed tomography or from fluoroscopy to complex angiography systems. This, however, comes with associated radiation risk for patients and staff. It is therefore vital that all X-ray equipment is monitored in terms of performance to ensure accurate and safe use. Quality control (QC) represents the basic level of managing safety and quality in diagnostic radiology. This publication compiles all existing QC tests in literature for all X-ray modalities. To facilitate the use of this handbook, spreadsheets and video tutorials have been developed to help with the execution of tests.