Peter Attia

If the first rule of cancer is “Don’t get cancer,” the second rule is “Catch it as soon as possible.”

The single most powerful item in our preventive tool kit is exercise, which has a two-pronged impact on Alzheimer’s disease risk: it helps maintain glucose homeostasis, and it improves the health of our vascula

As we’ll see in chapter 11, endurance exercise produces factors that directly target regions of the brain responsible for cognition and memory.

grip strength, an excellent proxy for overall strength, was strongly and inversely associated with the incidence of dementia

the greater someone’s grip strength, the lower their risk of dementia.

I now tell patients that exercise is, full stop and hands down, the best tool we have in the neurodegeneration prevention tool kit.

Sleep is also a very powerful tool against Alzheimer’s disease, as we’ll see in chapter 16. Sleep is when our brain heals itself; while we are in deep sleep our brains are essentially “cleaning house,”

Another somewhat surprising risk factor that has emerged is hearing loss. Studies have found that hearing loss is clearly associated with Alzheimer’s disease, but it’s not a direct symptom.

Another surprising intervention that may help reduce systemic inflammation, and possibly Alzheimer’s disease risk, is brushing and flossing one’s teeth.

(Remember, cognition is one of the three key vectors of healthspan.)