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Martin Casado,Erik Torenberg,Vishal Misra

Columbia CS Professor: Why LLMs Can’t Discover New Science

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From GPT-1 to GPT-5, LLMs have made tremendous progress in modeling human language. But can they go beyond that to make new discoveries and move the needle on scientific progress?

We sat down with distinguished Columbia CS professor Vishal Misra to discuss this, plus why chain-of-thought reasoning works so well, what real AGI would look like, and what actually causes hallucinations.
0:50:54
Publisher
a16z
Series
a16z
Publication year
2025
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