Dr. Keegan Wade is a highly successful trauma surgeon in New York City, but her career has left her feeling empty and anxious. In need of a break, she embarks on a journey across the country on a restored steam train. Along the way, she reunites with Willow Lord, a recent college graduate struggling to make ends meet. Despite their vastly different lives, Keegan and Willow share a deep connection that began many years ago as young girls. As they travel together on The Frisco Express, they rediscover their feelings for each other and explore the possibility of a second chance at love. But will their different lives and obligations keep them apart once the train journey ends?